ABSTRACT
Objectives@#The purpose of this study was to investigate the influence of anxiety, uncertainty, and cancer coping on the quality of life in breast cancer patients receiving neoadjuvant chemotherapy. @*Methods@#The participants of the study were 103 breast cancer patients who were in B Metropolitan City. Data had been collected between August 28 and November 22, 2020. For data analysis, SPSS/WIN 24.0 program was used, and descriptive, independent t-test, ANOVA and Scheffe’s test, and Pearson’s correlation coefficients and multiple regression were used for analysis. @*Results@#The most influencing factor on quality of life was anxiety (β=-.66, p<.001) which was followed by the number of chemotherapy treatments (β=.23, p<.001), interpersonal cancer coping(β=.18, p=.007) and inter-personal cancer coping (β=.18, p=.004). The overall explanatory power was 78.0%. @*Conclusion@#In order to improve the quality of life for breast cancer patients receiving neoadjuvant chemotherapy, it is necessary to develop a nursing program that may reduce their anxiety, promote cancer coping, and consider the number of their chemotherapy treatments.